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67Ga-EDTMP was synthesized in a single step by adding 67GaCl3 to EDTMP solution. Dependences ofthe radiolabeling yield of 67Ga-EDTMP on EDTMP concentration, pH and reaction time were examined. Under theoptimum conditions, the radiolabeling yield of 67Ga-EDTMP was more than 97%. A biodistribution experiment inmice showed that 67Ga-EDTMP was mainly absorbed by skeleton and reached 13.25% at 0.5 h after injecting, thenkept a high level in 72 h with a maximum value of 16.82% at 48 h. The results suggest that 67Ga-EDTMP might be apotential bone pain palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relativelylow soft-tissue absorption. But further work must be done to determine whether 67Ga-EDTMP is useful in thetreatment of painful osseous metastases.