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The cubic B-splines taken as trial function, the large deflection of a circular plate with arbitrarily variable thickness,as well as the buckling load, have been calculated by the method of point collocation. The support can be elastic. Loads imposed can be polynomial distributed loads, uniformly distributed radial forces or moments along the edge respectively or their combinations. Convergent solutions can still be obtained by this method under the load whose value is in great excess of normal one. Under the action of the uniformly distributed loads, linear solutions of circular plates with linearly or quadratically variable thickness are compared with those obtained by the parameter method. Buckling of a circular plate with identical thickness beyond critical thrust is compared with those obtained by the power series method.