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目的评价液基细胞薄层制片技术(LCT)在宫颈病变筛查中的临床应用价值,从而进一步研究宫颈癌发病情况及液基细胞学检查在妇科疾病诊断中的意义。方法利用液基薄层细胞制片技术(LCT)对16 698例宫颈标本进行细胞学检查,按Bethesda诊断系统(TBS)作出诊断,并对结果进行回顾性分析。结果 16 698例宫颈标本中,不满意标本57例,占0.34%;上皮细胞异常(阳性病例)1276例,占7.64%;鳞状细胞癌(SCC)21例,占0.12%;腺癌(AC)5例,占0.02%;高级别鳞状上皮内病变(HSIL)142例,占0.85%;低级别鳞状上皮内病变(LSIL)452例,占2.71%;非典型鳞状上皮细胞,不排除高级别鳞状上皮内病变(ASC-H)37例,占0.22%;非典型鳞状上皮细胞,意义不明确(ASC-US)581例,占3.47%;非典型腺细胞(AGC)38例,占0.22%;未见上皮内病变或恶性病变(NILM)15 364例,占92.07%。结论 LCT和TBS系统能全面准确地反映宫颈病变情况。早期发现癌前病变,及时治疗,阻止宫颈上皮内病变升级是防治宫颈癌的关键。
Objective To evaluate the clinical value of LCT in the screening of cervical lesions and to further study the incidence of cervical cancer and the significance of liquid-based cytology in the diagnosis of gynecological diseases. Methods Totally 16 698 cervical specimens were examined by liquid-based TLCT and diagnosed by Bethesda Diagnostic System (TBS). The results were retrospectively analyzed. Results Among 16 698 cervical specimens, 57 were unsatisfactory (0.34%), 1276 were epithelial abnormalities (positive), accounting for 7.64%, 21 were squamous cell carcinoma (SCC), accounting for 0.12% ), 5 cases (0.02%); high grade squamous intraepithelial lesion (HSIL) 142 cases, accounting for 0.85%; low grade squamous intraepithelial lesion (LSIL) 452 cases, accounting for 2.71%; atypical squamous epithelial cells, not There were 37 cases (0.22%) with high grade squamous intraepithelial lesion (ASC-H) excluded, 581 cases (3.47%) with atypical squamous cell carcinoma (ASC-US) , Accounting for 0.22%; no intraepithelial lesion or malignant lesions (NILM) 15 364 cases, accounting for 92.07%. Conclusion LCT and TBS system can fully and accurately reflect the cervical lesions. Early detection of precancerous lesions, timely treatment, to prevent cervical epithelial lesions upgrade is the key to prevention and treatment of cervical cancer.