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许多有机磷化合物对人体危害很大,其作用主要是抑制胆硷酯酶的活性。反应机理是由于有机磷酸酯和胆硷酯酶结合成酶—抑制物复合体,而后生成磷酰化胆硷酯酶,后者失去了催化乙酰胆硷水解的能力,使胆硷
Many organophosphorus compounds on the human body is very harmful, its role is to inhibit the activity of cholinesterase. The reaction mechanism is due to organic phosphate and cholinesterase enzyme-inhibitor complexes, and then phosphorylated cholinesterase, which lost the ability to catalyze the hydrolysis of acetylcholine, the choline