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在一项新的研究中,来自美国纽约大学朗格尼医学中心和俄罗斯科学院的研究人员发现一种关键的生物化学分子pp Gpp能够让细菌修复它们DNA上的致命性损伤,包括抗生素导致的DNA损伤。相关研究结果发表在Science期刊上。研究人员说,在未来的治疗中,调整pp Gpp分子的作用可能破坏细菌的DNA修复能力,从而使得它们对现存的抗生素敏感性提高好多倍。根据美国疾病控制与预防中心的说法,细菌重复性地接触相同的药物会产生耐药性,而且在美国,耐药性细菌感染每年与23,000例死亡和200
In a new study, researchers from the University of New York Lloyd’s Medical Center and the Russian Academy of Sciences found that a key biochemical molecule, pp Gpp, enables bacteria to repair deadly damage to their DNA, including antibiotic-induced DNA damage. Relevant research results published in Science journals. In future treatments, the researchers say, adjusting the role of pp Gpp molecules could undermine bacterial DNA repair capabilities, making them many times more sensitive to existing antibiotics. According to the Centers for Disease Control and Prevention, bacteria repeatedly develop resistance to the same drugs, and in the United States, drug-resistant bacterial infections are associated with 23,000 deaths each year and 200