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1993年2月至1994年12月对87例食管癌患者进行大剂量短程术前放疗,86例做了食管癌切除颈部Gambee's吻合术,1例单纯探查(Ⅰ组)。同期食管癌患者99例,行单纯手术治疗(Ⅱ组),作为对照组。放疗方法:20~25GY/4~5次/4~5天,放疗后1~7天行手术治疗。结果:全部患者均可耐受大剂量放疗。术中见肿瘤变软、缩小;手术出血量、手术时间、术后并发症与对照组相比无明显差异。手术切除率:Ⅰ组99%(86/87),Ⅱ组89%(88/99),P<0.05。手术死亡率:Ⅰ组0,Ⅱ组2%(2/99)。术后生存率:1年Ⅰ组68.6%(59/86),Ⅱ组64.8%(57/88);2年Ⅰ组50.0%(43/86),Ⅱ组46.6%(41/88);3年Ⅰ组46.9%(15/32),Ⅱ组37.5%(12/32)。
From February 1993 to December 1994, 87 cases of esophageal cancer were treated with high-dose short-range preoperative radiotherapy, 86 cases had undergone Gambe’s anastomosis of the neck of esophageal cancer, and 1 case of simple exploration (group I). In the same period, 99 patients with esophageal cancer underwent surgery alone (Group II) as a control group. Radiotherapy: 20 ~ 25GY / 4 ~ 5 times / 4 ~ 5 days, 1 ~ 7 days after radiotherapy surgery. Results: All patients can tolerate high-dose radiation therapy. During surgery, the tumor became soft and narrow; there was no significant difference in the amount of blood loss, operation time, and postoperative complications compared with the control group. The surgical resection rate was 99% (86/87) in group I and 89% (88/99) in group II, P<0.05. Surgical mortality: I group 0, II group 2% (2/99). Postoperative survival rate: 68.6% (59/86) in group I for 1 year, 64.8% (57/88) in group II, 50.0% (43/86) in group 2 for 2 years, and group 46.6 in group 2 % (41/88); 46.9% (15/32) in group I for 3 years and 37.5% (12/32) in group II.