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用冠脉Harris二期结扎并部分再灌注及吻合支缝扎法造成犬急性前壁心肌梗塞 ,5 - 8天后辅以心室程控刺激技术 (PES)进行心电生理检查及复制快速室性心律失常 ,观察甲基莲心碱 (Neferine)抗心律失常的电生理作用并与普鲁卡因胺(PA)对比。结果表明 ,Neferine可显著延长QTc间期 (P <0 0 1)及正常心肌和缺血心肌的有效不应期 (NERP及IERP) (P <0 0 1) ,提高正常心肌和缺血心肌舒张期兴奋阈值 (NET及IET) (P <0 0 1) ,缩小缺血心肌和左室心肌ERP离散度 (IDR和VDR) (P <0 0 1) ,抑制心室PES诱发的持续性室速 (SVT)或室颤 (VF) (P <0 0 1) ,并能有效地预防犬慢性心肌梗塞后再次缺血所致的自发性VF (P <0 0 5 ) ,表明Neferine有抗缺血性快速室性心律失常的作用 ,并具有与PA相似的心电生理和抗心律失常作用
Acute anterior myocardial infarction in dogs was induced by coronary second-phase Harris ligation and partial reperfusion and anastomosing branch sutures. Ventricular electrophysiological examination and ventricular tachyarrhythmia (PES) were performed 5-8 days later with rapid ventricular arrhythmias , Observe the electrophysiological effects of Neferine anti-arrhythmia and compare with procainamide (PA). The results showed that Neferine significantly prolonged the QTc interval (P <0.01) and the effective refractory period (NERP and IERP) of normal and ischemic myocardium (P <0.01), and increased the diastolic function of normal myocardium and ischemic myocardium (P <0.01), reduced ERP dispersion (IDR and VDR) in ischemic myocardium and left ventricular myocardium (P <0.01), and inhibited ventricular PES-induced persistent ventricular tachycardia (IET) SVT or VF (P <0.01), and could effectively prevent spontaneous VF caused by re-ischemia in dogs with chronic myocardial infarction (P <0 05), indicating that Neferine has anti-ischemic Rapid ventricular arrhythmia and has similar electrophysiological and anti-arrhythmic effects to PA