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目的探讨常规体外受精胚胎移植(IVF-ET)过程中卵母细胞完全受精失败的临床原因。方法选择2009年2月至2010年10月常规IVF-ET治疗周期。根据受精情况分成受精障碍组62例和受精正常组722例,对两组的女方年龄、体重、不孕年限、不孕原因、获卵数、成熟卵比率、男方精液参数进行分析。结果两组间患者的体重、不孕年限、获卵数、成熟卵比率无统计学意义。受精障碍组女方年龄及原发不孕比例显著增高,伴有不明原因性和男方弱、畸形精子症受精障碍发生率高。结论体外受精胚胎移植中,女方年龄大、原发不孕、不明原因或(和)男方有弱、畸精症的患者可能存在受精失败,及时预测早期补救。
Objective To investigate the clinical causes of failure of complete oocyte fertilization during routine in vitro fertilization embryo transfer (IVF-ET). Methods The routine IVF-ET treatment cycles from February 2009 to October 2010 were selected. According to fertilization conditions, 62 cases of fertilization disorders and 722 cases of fertilization normal group were divided into two groups according to the age, weight, duration of infertility, causes of infertility, the number of oocytes retrieved, the ratio of mature eggs and the sperm parameters of men. Results The body weight, duration of infertility, the number of oocytes retrieved and the ratio of mature eggs between the two groups were not statistically significant. Fertilization group, the age of women and the proportion of primary infertility was significantly higher, with unexplained causes and weak man, deformity sperm disorder high incidence of fertilization disorders. Conclusion In IVF embryo transfer, women of older age, primary infertility, unexplained causes, and (or) men with weak, abnormalities may have fertilization failure, timely prediction of early recovery.