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目的比较不同的氨甲喋呤(MTX)给药方式治疗异位妊娠的疗效及副反应。方法回顾性分析我院2007年1月-2009年9月MTX药物保守治疗异位妊娠患者。其中A组(86例)采用MTX50mg/m2,单次肌注,最多不超过3个疗程。B组(74例)采用MTX-CF(甲酰四氢叶酸)方案:MTX1mg/kg隔日肌注,第1,3,5,7天,CF0.1mg/kg,第2,4,6,8天。两组患者均定期复查血β-HCG、阴超、血常规及肝肾功能,并每日严密观察生命体征、腹痛及阴道流血情况。结果单次给药与多次给药成功率无明显差异,但从两者用药后患者副反应表现来看,单次给药副反应要少。结论单次给药用量少,副反应小,易被患者接受。
Objective To compare the efficacy and side effects of different methotrexate (MTX) administrations in the treatment of ectopic pregnancy. Methods A retrospective analysis of our hospital from January 2007 to September 2009 MTX drug conservative treatment of ectopic pregnancy patients. A group (86 cases) using MTX50mg / m2, a single intramuscular injection, up to no more than 3 courses. In group B (74 cases), the MTX-CF (leucovorin) regimen was used: intramuscular injection of MTX1mg / kg every other day, on day 1,3,5,7, CF0.1mg / kg, day. Both groups of patients were regularly reviewed blood β-HCG, overcast, blood and liver and kidney function, and close daily observation of vital signs, abdominal pain and vaginal bleeding. Results There was no significant difference in the success rates between single administration and multiple administrations. However, the side effects of single administration were less after the administration of both drugs. Conclusion Single administration with less side effects, easy to be accepted by patients.