MM癌干细胞的生物学特性及靶向治疗策略

• 作 者: 杨翠萍 窦骏
• 机 构: 东南大学医学院病原生物学与免疫学系,
• 出 处: 现代免疫学
• 发表日期: 2013年02期
• 关键词: 癌干细胞 MM 靶向药物 多发性骨髓瘤 生物学特性 恶性浆细胞疾病 自我更新 信号通路 核转录因子 细胞系

多发性骨髓瘤(MM)是浆细胞的恶性肿瘤,几乎100%患者发生复发,迄今,仍是不可治愈的疾病。近来研究表明MM癌干细胞(CSC)的存在是导致其耐药和复发的根源,研究发现MM CSC具有自我更新、分化及较强的侵袭性、耐药性及致瘤性等特性。针对CSC分子靶向治疗已成为肿瘤治疗的新的关注点。目前MM CSC的靶向策略主要有靶向信号通路、耐药分子、CD分子、HLA-I分子、IL-6分子、核转录因子-κB以及端粒酶等,本文就MM CSC的生物学特性及其靶向治疗策略综述如下。

Multiple myeloma (MM) is a plasma cell malignancy that recovers in almost 100% of patients and remains untreatable until now. Recent studies have shown that the presence of MM cancer stem cells (CSCs) is the root cause of drug resistance and relapse. The study found that MM CSC has the characteristics of self-renewal, differentiation and strong invasion, drug resistance and tumorigenicity. Targeting CSC molecules has become a new focus of cancer treatment. Currently MM CSC targeting strategies mainly target signal pathways, drug resistance molecules, CD molecules, HLA-I molecules, IL-6 molecules, nuclear factor-κB and telomerase, the biological characteristics of MM CSC And its targeted treatment strategies are summarized below.