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血管紧张素转换酶(ACE)抑制剂降低高血压糖尿病鼠尿蛋白排泄及保护肾功能的作用较其他抗高血压药物显著。已证实地尔硫(艹卓)(Diltiazem)对肾血液动力学的作用与ACE抑制剂相似。本文报道患有肾性蛋白尿的糖尿病高血压患者使用地尔硫(艹卓)及赖诺普利(Lisinopril)的疗效。
Angiotensin converting enzyme (ACE) inhibitors reduce urinary protein excretion and protect renal function in hypertensive diabetic mice than other antihypertensive drugs. Diltiazem has been shown to exert similar effects on renal hemodynamics as ACE inhibitors. This article reports the efficacy of diltiazem and lisinopril in diabetic hypertensive patients with renoproteinuria.