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在脂蛋白代谢障碍的药物治疗讨论中,这些药物的作用有两种基本方式被认为是合适的.一种方式是其对脂蛋白的作用,这些脂蛋白的主要功能是将胆固醇(CH)、甘油三酯(TG)或二者从内脏区(即肝脏和小肠)转移至周围组织.这些脂蛋白内含有载脂蛋白(apo)B,就乳糜微粒来说为apoB_(48),对极低密度、中等密度和低密度脂蛋白(分别略为VLDL、IDL和LDL)来说则为apoB_(100)降脂药物的绝大多数研究集中于含apoB_(100)的脂蛋白.这些药物作用的另一种方式是其对高密度脂蛋白(HDL)的作用.HDL在CH自周围组织运回肝脏这一反向转运过程中起主要作用.
In the drug treatment discussion of lipoprotein metabolism disorders, there are two basic ways in which the effects of these drugs can be considered: One way is their effect on lipoproteins whose primary function is to separate cholesterol (CH), Triglyceride (TG), or both, is transferred from the visceral region (ie, the liver and small intestine) to the surrounding tissues.These lipoproteins contain apolipoprotein B, apoB_ (48) for chylomicrons, The vast majority of studies of apoB_ (100) lipid-lowering drugs with density, medium density, and low density lipoproteins (slightly VLDL, IDL, and LDL, respectively) focused on apoB_ (100) containing lipoproteins. One way is its effect on high-density lipoproteins (HDL), which plays a major role in the reverse transport of CH from the surrounding tissue back to the liver.