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目的研究氨溴索对COPD患者血清细胞因子及肺功能的影响及愈后。方法将南阳市第一人民医院80例COPD患者随机分为治疗组与对照组两组每组40例,均进行常规治疗,而治疗组加用氨溴索,对所有患者进行治疗前、后进行血清细胞因子及肺功能检测,并进行对比分析。结果两组COPD患者治疗前后血清细胞因子测定IL-8、IL-10、TNF-α,肺功能的比较FEV1%、FEV1/FVC、MVV、MMEF%皆有明显好转,但运用氨溴索的治疗组较常规治疗的对照组好转更明显。结论氨溴索可以减轻炎症反应,改善COPD的病理基础,有利于改善患者的肺功能,解除缺氧和二氧化碳潴留,减轻症状,改善临床预后等优点。
Objective To study the effect of ambroxol on serum cytokines and lung function in COPD patients and its prognosis. Methods 80 patients with COPD in First People’s Hospital of Nanyang City were randomly divided into treatment group and control group, 40 cases in each group. All patients were treated routinely. Patients in treatment group were given ambroxol and all patients were treated before and after treatment Serum cytokines and lung function tests, and comparative analysis. Results The serum levels of IL-8, IL-10, TNF-α and pulmonary function in two groups of patients with COPD before and after treatment were significantly better than those of FEV1%, FEV1 / FVC, MVV and MMEF% Compared with the conventional treatment group, the improvement of the control group was more obvious. Conclusion Ambroxol can relieve inflammation, improve the pathological basis of COPD, improve lung function, relieve hypoxia and carbon dioxide retention, relieve symptoms and improve clinical prognosis.