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目的研究替米沙坦对老年原发性高血压(EH)患者的降压作用和对左室肥厚(LVH)的影响。方法选择52例老年EH患者,其中有LVH者20例,口服替米沙坦40～80mg/d,为期6个月。观察血压、不良反应,治疗前后测血脂、血糖和肝肾功能,并作二维超声心动图检测采用自身前后对照的实验方法。结果老年EH患者经替米沙坦治疗后收缩压舒张压显著下降(P<0.01),其中LVH者治疗后左心室舒张末期内径及左室重量均明显下降(P<0.05),舒张末期左室后壁厚度、室间隔厚度及左室重量指数下降更明显(P<0.01)。结论替米沙坦治疗EH安全、有效、并且可逆转LVH。
Objective To investigate the antihypertensive effects of telmisartan on left ventricular hypertrophy (LVH) in elderly patients with essential hypertension (EH). Methods Fifty-two elderly EH patients were selected, including 20 with LVH and 40-80 mg / d of telmisartan for 6 months. Blood pressure, adverse reactions were observed before and after treatment of blood lipids, blood glucose and liver and kidney function, and for two-dimensional echocardiography test using its own control before and after the experimental method. Results The systolic pressure and diastolic pressure of elderly patients with EH were significantly decreased after treatment with telmisartan (P <0.01), and the left ventricular end diastolic diameter and left ventricular weight were significantly decreased in LVH patients after treatment (P <0.05) Thickness of posterior wall, interventricular septum thickness and left ventricular mass index decreased more significantly (P <0.01). Conclusion Telmisartan is safe and effective in treating EH and reversing LVH.