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旋光异构体具有不同的生理作用,如D-(-)异丙肾上腺素对支气管舒张作用比L-(+)型异构体强50～800倍;(-)-抗坏血酸有抗坏血病作用,而(+)-抗坏血酸则无此作用;解毒剂D-青霉胺毒性很小,剂量每天可达1g,而L-异构体毒性很大,在D-青霉胺中如含有1%的L-异构体就会产生毒性反应。鉴此,在药物研究中为了提高药物的生理活性、减少副作用以及深入研究药物的作用机制,均要求提供光学纯的药物,因而对映体的拆分技术是一具有理论和实际意义的课题。
Optical isomers have different physiological effects, such as D - (-) isoproterenol bronchodilator relaxation of the L - (+) isoform stronger than 50 to 800 times; (-) - Ascorbate have anti-scurvy (+) - ascorbic acid is no such effect; antidote D-penicillamine toxicity is very small, the dose up to 1g per day, while the L-isomer toxicity is very large, such as in D-penicillamine containing 1 % Of the L-isomer produces a toxic reaction. In view of this, in drug research in order to improve the physiological activity of drugs, reduce side effects and in-depth study of the mechanism of action of drugs are required to provide optically pure drugs, and therefore enantiomer resolution technology is a theoretical and practical issues.