论文部分内容阅读
目的:分析北京市人类免疫缺陷病毒（HIV）感染者/艾滋病（AIDS）患者合并乙型肝炎病毒（HBV）感染的流行病学特征，并探索影响合并感染的相关因素。方法:对北京地区HIV/AIDS定点治疗医院（北京协和医院、北京地坛医院、北京佑安医院）长期随访的接受抗反转录病毒治疗（ART）的13 253例HIV感染者临床资料进行回顾性分析。结果:排除未进行HBV标志物检测的患者1 681例， 共有11 572例HIV感染者纳入研究，其中HIV合并HBV感染的患者532例（4.6%），主要为青壮年（28~48岁）男性，占 85.9%，感染途径以同性性传播为主（74.8%）。87.4%的合并感染患者基线治疗接受了包含拉米夫定（3TC）、替诺福韦（TDF）两种抗HBV药物的治疗。2013—2018年，HIV合并HBV感染的年新增感染率呈波动性下降的趋势，年均增长率分别为 6.37%、4.55%、3.92%、4.68%、4.24%和2.74%。HIV合并HBV感染的主要影响因素为年龄（28~48岁比<28岁，n OR=2.807， 95%n CI 1.241~6.345）以及婚姻状况（已婚比未婚，n OR=1.259， 95%n CI 1.004~1.579）。n 结论:北京地区HIV合并HBV感染率为4.6%；2013—2018年HIV合并HBV的年新增合并感染率呈下降趋势。青壮年（28~48岁）已婚HIV感染者合并HBV感染的风险较高。“,”Objective:To analyze the epidemiological characteristics of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients in Beijing and investigate the associated factors.Methods:The clinical data of patients with HIV infection who were treated in HIV/AIDS designated hospitals (Peking Union Medical College Hospital, Beijing Ditan Hospital and Beijing Youan Hospital) were retrospectively analyzed.Results:A total of 11 572 patients were finally included in the study, among whom 532 patients (4.6%) were co-infected with HIV and HBV. Most of the co-infected patients were young male adults (28~48 years old), accounting for 85.9%. The main transmission route was homosexual behavior (74.8%). There were 87.4% co-infected patients treated with two anti-HBV drugs, including lamivudine (3TC) and tenofovir (TDF). From 2013 to 2018, the annual prevalence of HIV and HBV co-infection decreased gradually, with the rate of 6.37%, 4.55%, 3.92%, 4.68%, 4.24% and 2.74%, respectively. In our study, The main influencing factors of HIV and HBV co-infection were age older than 28 years old versus<28 years old (n OR=2.807, 95%n CI 1.241-6.345) and marriage status (married versus unmarried, n OR=1.259, 95%n CI 1.004-1.579).n Conclusions:The proportion of HBV infection in HIV-infected patients is 4.60% (532) in our cohort. From 2013 to 2018, the prevalence of HIV and HBV co-infection in Beijing shows a decreasing trend. The risk of co-infection is higher in married young adults (28~48 years old).