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目的探讨妊娠妇女孕早期血清超敏C-反应蛋白(hs-CRP)在预测妊娠糖尿病(GDM)中的价值。方法收集琼海市人民医院院产科门诊进行产检的孕妇538例进行前瞻性研究,跟踪随访致孕中期,根据孕中晚期75g糖耐量结果区分出GDM、糖耐量异常(IGT)。排除有GDM高风险因素的孕妇后,分作GDM组和IGT组,及把孕周和年龄相同的正常孕妇作为对照组,分别对3组血清hs-CRP进行分析。结果 GDM的发生率为5.6%,IGT的发生率为4.9%。GDM组血清hs-CRP明显高于IGT组和对照组(P<0.05,P<0.01);孕前BMI与hs-CRP呈正相关;孕前体重指数(BMI)与血清hs-CRP存在正相关。结论孕早期血清hs-CRP水平高低对GDM有预测价值。
Objective To investigate the value of serum hs-CRP in pregnant women in the prediction of gestational diabetes mellitus (GDM) in early pregnancy. Methods A total of 538 pregnant women were collected from obstetrics and gynecology clinics in Qionghai People ’s Hospital for follow - up and follow - up. The GDM and IGT were distinguished according to the results of 75g glucose tolerance test. After exclusion of pregnant women with high GDM risk factors, the patients were divided into GDM group and IGT group, and the normal pregnant women with the same gestational age and same age as the control group. The serum hs-CRP level in the three groups were analyzed respectively. Results The incidence of GDM was 5.6% and the incidence of IGT was 4.9%. The serum hs-CRP level in GDM group was significantly higher than that in IGT group and control group (P <0.05, P <0.01). BMI was positively correlated with hs-CRP before pregnancy. BMI and serum hs-CRP were positively correlated. Conclusion The serum hs-CRP level in early pregnancy may have predictive value for GDM.