在挑选的和非挑选的人群中妊娠早期时的颈部半透明厚度、鼻骨及21-三体的关系

• 作 者: Prefumo F. Sairam S. Bhide A. Thilaganathan B. 张新艳
• 机 构: Fetal Medicine Unit St. George\' s,University of London Lanesborough Wing Blackshaw Road London S
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年Z1期
• 关键词: 妊娠早期 三体 鼻骨 阴性预测值 保健中心 骨显像 特异度

Objective: The purpose of this study was to assess the role of fetal nasal bones evaluation in first- trimester screening for trisomy 21 in selected and unselected pregnancies. Study design: Visualization of the nasal bones was attempted in women attending for routine nuchal translucency screening (unselected population, n = 7116, 12 cases of trisomy 21), aswell as in high risk pregnancies referred to our tertiary care center (selected population, n = 510, 23 cases of trisomy 21). Results: The sensitivity, specificity, positive and negative predictive value of absent nasal bones for trisomy 21 were 16.7% , 97.3% , 1.1% , 99.8% and 47.6% , 95.3% , 33.3% , 97.4% in the unselected and selected population, respectively. At logistic regression analysis including nuchal translucency and nasal bones findings, the latter resulted to be an independent predictor of trisomy 21 in the selected but not in the unselected population. Conclusion: First- trimester nasal bones assessment for trisomy 21 screening has a very different performance in selected and unselected pregnancies.

Objective: The purpose of this study was to assess the role of fetal nasal bones in evaluation of first- trimester screening for trisomy 21 in selected and unselected pregnancies. Study design: Visualization of the nasal bones was attempted in women attending for routine nuchal translucency screening ( unselected population, n = 7116, 12 cases of trisomy 21), aswell as in high risk pregnancies referred to our tertiary care center (selected population, n = 510, 23 cases of trisomy 21). Results: The sensitivity, specificity, positive and negative predictive value of absent nasal bones for trisomy 21 were 16.7%, 97.3%, 1.1%, 99.8% and 47.6%, 95.3%, 33.3%, 97.4% in the unselected and selected population, respectively. At logistic regression analysis including nuchal translucency and nasal bones findings, the latter resulted in be an independent predictor of trisomy 21 in the selected but not in the unselected population. Conclusion: First- trimester nasal bones assessment for trisomy 21 screening has a very different performance in Selected and unselected pregnancies.