牛源性与重组人透明质酸酶在同胞卵子受精率及胚胎形态作用比较:一项预期、盲式、随机研究

• 作 者: Taylor T.H. Elliott T. Colturato L.F. Z.P. Nagy 马艳华
• 机 构: Reproductive Biology Associates Atlanta GA United States Dr. ,
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年11期
• 关键词: 卵子受精 透明质酸酶 随机研究 胚胎 显微注射 精子 卵母细胞 卵子 胚胎发育 受精率

The objective of the present study was to compare a traditionally used bovine-derived hyaluronidase (Hyase) with the newly developed recombinant human-derived enzyme product (Cumulase) in intracytoplasmic sperm injection (ICSI) procedures using a sibling oocyte model in a prospective randomized design. The results of the study demonstrate that Cumulase is safe and effective in an ICSI treatment program and can provide comparable if not improved parameters, including fertilization and embryo developmental rates.

The objective of the present study was to compare a traditionally used bovine-derived hyaluronidase (Hyase) with the newly developed recombinant human-derived enzyme product (Cumulase) in intracytoplasmic sperm injection (ICSI) procedures using a sibling oocyte model in a prospective randomized design The results of the study demonstrate that Cumulase is safe and effective in an ICSI treatment program and can provide comparable if not improved parameters, including fertilization and embryo developmental rates.