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A—Ⅲ系锦葵科植物黄蜀蔡中提取的一种结晶状单体,临床发现局部应用对多种口腔溃疡,炎症有快速良好的止痛效果。本文报道对AⅢ镇痛作用的实验研究结果。 一、镇痛实验 小鼠扭体法:12—20g小白鼠,随机分用药组(n=11)和生理盐水(NS)组(n=12)分背部皮下注射1％A—Ⅲ和Ns0.5ml/只给药后30分钟和60分钟用0.05％酒石酸锑钾引起扭体。结果给药组30分钟时扭体数/10分钟为14.5±11.5,NS组为3.13±13.2,两组比较P0.01,表明A-Ⅲ能明显抑制小鼠扭
A-III is a crystalline monomer extracted from Amaranthus radix in the Amaranthaceae plant. It was found that topical application has a rapid and good analgesic effect on a variety of oral ulcers and inflammation. This article reports the results of an experimental study of the analgesic effect of AIII. First, the analgesic experiment mice writhing method: 12-20g mice, randomized drug group (n = 11) and saline (NS) group (n = 12) subcutaneous injection of 1% A-III and Ns0 sub. The writhing was induced with 0.05% potassium bismuth tartrate after 30 minutes and 60 minutes after 5 ml/administration. Results Tweaked body number/10 minutes at the 30th minute in the administration group was 14.5±11.5, and 3.13±13.2 in the NS group. P0.01 in the two groups showed that A-III could significantly inhibit the mice’s twist