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目的:观察慢性心力衰竭(CHF)患者心肌损伤指标肌钙蛋白I(cTnI)和炎症指标超敏C反应蛋白(hs-CRP)含量变化并探讨其与CHF不同类型及B型钠尿肽(BNP)之间的关系。方法:选择经临床确诊的CHF患者160例(NYHAⅠ-Ⅳ级),健康对照者150名,无CHF的心血管患者142例。用免疫荧光定量分析法测定其全血hs-CRP和BNP水平,微粒子酶促化学发光免疫分析法测定其血清cTnI水平,并进行对比分析。结果:CHF患者组全血BNP和hs-CRP水平均显著高于无CHF的心血管患者组和健康对照组,血清cTnI值CHF患者组亦均显著高于无CHF的心血管患者组和健康对照组(P均<0.01)。且随心功能NY-HA分级的增高,全血BNP水平逐渐升高,组间差别均有统计学意义,而全血hs-CRP与血清cTnI水平随心功能NYHA分级的增高,组间差别均无统计学意义(P均>0.05),但均较健康对照组升高。结论:慢性心力衰竭疾病过程中存在着心肌损伤和炎症,表明心肌损伤和炎症是这种疾病病理生理过程的重要成分,但这种心肌损伤和炎症与心功能NYHA分级和障碍程度无关。
Objective: To observe the changes of cardiac troponin I (cTnI) and inflammation index hs-CRP in patients with chronic heart failure (CHF) and to explore its relationship with different types of CHF and BNP )The relationship between. Methods: 160 clinically diagnosed CHF patients (NYHAⅠ-Ⅳ grade), 150 healthy controls and 142 cardiovascular patients without CHF were enrolled. The levels of hs-CRP and BNP in whole blood were determined by immunofluorescence quantitative analysis. The level of cTnI in serum was detected by microparticle enzyme-linked chemiluminescence immunoassay and compared. Results: The levels of plasma BNP and hs-CRP in CHF patients were significantly higher than those in non-CHF patients and healthy controls. Serum cTnI values in CHF patients were also significantly higher than those in non-CHF patients and healthy controls Group (all P <0.01). BNP levels in whole blood increased gradually with the NY-HA classification of heart function, and there was significant difference between the two groups. However, the levels of hs-CRP and cTnI in whole blood increased with the NYHA classification, but there was no statistical difference Significance (P> 0.05), but higher than the healthy control group. CONCLUSIONS: Myocardial injury and inflammation are present in the pathogenesis of chronic heart failure, suggesting that myocardial injury and inflammation are important components of the pathophysiology of the disease. However, this type of myocardial injury and inflammation is not associated with NYHA classification and extent of cardiac function.