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目的:探讨中期妊娠引产应用米非司酮与米索前列腺醇联合羊膜腔内注射利凡诺的有效性与安全性。方法:是选择2006年1月—2009年3月在本院要求引产的孕14~27周无禁忌的妇女。观察组30例,一次性口服米非司酮150mg,后羊膜腔内注射利凡诺顿100mg,24h后米索200μg口服,无规则宫缩1h后200μg阴道给药。对照组30例,按传统的方法单纯的羊膜腔内注射利凡诺100mg。两组年龄、职业、孕产次、孕周等均无明显差异。比较这两种方法的临床效果和副作用。结果:观察组较对照组宫缩的发动时间提前,从诱导至分娩的时间、总产程均较单纯羊膜腔内注射利凡诺组明显缩短,其24h及48h分娩率明显高于利凡诺组,两组产后出血、月经不调等的发生率无显著差异,米非司酮及米索服药后轻度恶心呕吐均为一过性,不需特殊处理。结论:米非司酮、米索、联合利凡诺用于中期妊娠较传统单用利凡诺的引产效果好.。
Objective: To investigate the efficacy and safety of mifepristone and misoprostol combined with amniotic injection of rivanol in second trimester induction of labor. Methods: Select the January 2006 -2009 March in our hospital for induction of labor 14 to 27 weeks pregnant women without contraindication. The observation group of 30 cases, a single oral administration of mifepristone 150mg, after amniotic cavity injection of Rivanol Norton 100mg, 24h misoprostol 200μg orally, no contractions after 1h 200μg vaginal administration. Control group of 30 patients, according to the traditional method of simple amniotic injection of rivanol 100mg. There were no significant differences between the two groups in terms of age, occupation, pregnancy, parity and gestational age. Compare the clinical effects and side effects of these two methods. Results: Compared with control group, the onset time of uterine contractions in the observation group was earlier than that in the control group. The time from induction to delivery was shorter than that in the simple amniotic injection of rivanol group. The delivery rates at 24h and 48h were significantly higher than those in the rivanol group There was no significant difference in the incidence of postpartum hemorrhage and irregular menstruation in both groups. Mifepristone and misoprostol were mildly nausea and vomiting without special treatment. CONCLUSION: Mifepristone, misoprostol, and rivanol are more effective in inducing labor than the conventional rivanol in the second trimester.