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目的:运用3种方案治疗合并胰岛素抵抗的多囊卵巢综合症患者疗效研究,进而探讨出治疗该种病症的有效方案。方法:选取我站2012年3月~2015年3月收治的62例多囊卵巢综合症患者作为研究对象,年龄在24~38岁。并将所有患者进行随机分成三组,行为治疗方案,二甲双胍治疗方案,罗格列酮治疗方案,总结患者治疗前后的。记录规律月经率,排卵率,体重指数,腰围和臀围比,总胆固醇,睾酮,甘油三酯,空腹血糖,低密度蛋白胆固醇,空腹胰岛素等指标的变化。结果:3种治疗方案对腰围和臀围比,体重指数,睾酮,空腹血糖,空腹胰岛素水平明显下降。其中罗格列酮组患者治疗后规律月经和排卵率相对较高。结论:对多囊卵巢综合征患者的胰岛素增敏治疗对降低睾酮,空腹胰岛素,空腹血糖以及体重方面取得了良好的效果,并且患者的排卵和不规律月经症状得到了有效的改善。在对患者使用二甲双胍与罗格列酮药物进行治疗时应慎重。对多囊卵巢综合征患者进行个体化治疗时,胰岛素增敏与其他药物联合使用,能够提升对该种病症的治疗效果。
OBJECTIVE: To study the efficacy of three kinds of regimens in the treatment of patients with polycystic ovary syndrome complicated by insulin resistance, and to explore an effective plan for the treatment of such diseases. Methods: Sixty-two patients with polycystic ovary syndrome who were treated in our hospital from March 2012 to March 2015 were selected as the study subjects, aged from 24 to 38 years old. All patients were randomly divided into three groups, behavioral therapy, metformin treatment, rosiglitazone treatment, summary of patients before and after treatment. The changes of menstrual rate, ovulation rate, body mass index, waist circumference and hip-to-hip ratio, total cholesterol, testosterone, triglyceride, fasting blood glucose, low density protein cholesterol and fasting insulin were recorded. Results: The three kinds of treatment regimens showed a significant decrease in waist circumference and hip circumference, body mass index, testosterone, fasting blood glucose and fasting insulin. Among them, rosiglitazone group had a higher regular menstruation and ovulation rate after treatment. CONCLUSIONS: Insulin sensitization in patients with PCOS achieved good results in lowering testosterone, fasting insulin, fasting glucose and body weight, and ovulation and irregular menstruation were effectively ameliorated. Care should be taken when using metformin with rosiglitazone in patients. Individual treatment of polycystic ovary syndrome patients, insulin sensitization combined with other drugs, can enhance the treatment of the disease effect.