川芎嗪防治大鼠实验性肺水肿的电镜观察

• 作 者: 戴顺龄 苏树芸 程凯 邹宇宏 薛全福
• 机 构: 中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,中国医学科学院基础医学研究所,
• 出 处: 中西医结合杂志
• 发表日期: 1987年11期
• 关键词: 川芎嗪 肺泡上皮细胞 预防组 内皮细胞肿胀 结缔组织增生 肺泡腔 大鼠 超微结构观察 治疗作用 间质

本文论述川芎嗪对肾上腺素所致肺水肿预防与治疗作用的超微结构观察。肺水肿时可见间质腔与肺泡腔水肿,上皮细胞和内皮细胞肿胀、变性、脱落,基底膜裸露、断裂。而川芎嗪预防组和治疗组上述病变明显减轻,仅见间隔结缔组织增生,血管内皮、肺泡上皮细胞接近正常,与光镜观察及其他测定指标一致。

This article discusses the ultrastructural observation of the preventive and therapeutic effects of tetramethylpyrazine on pulmonary edema induced by epinephrine. Pulmonary edema can be seen in the interstitial cavity and alveolar cavity edema, epithelial cells and endothelial cells swelling, degeneration, loss, basement membrane exposed, fracture. The above-mentioned lesions in the tetramethylpyrazine prevention group and the treatment group were significantly reduced. Only the connective tissue hyperplasia was observed, and the vascular endothelium and alveolar epithelial cells were close to normal, which was consistent with light microscope observation and other measurement indicators.