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目的:对心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)和肌红蛋白(Mb)进行定量分析比较,对急性心肌梗死(AMI)的早期诊断和风险预测提供较为可靠的检测指标。方法:对85例急性冠状动脉综合征患者(ACS)在入院后24 h内检测cTnI、CK-MB和Mb的质量水平,探讨它们对AMI的敏感性和特异性,并进行评估。结果:患者入院后24 h内cTnI、CK-MB和Mb对AMI的敏感性分别为93.3%,86.7%和78.3%,特异性分别为100%,100%和88.0%;同时检测cTnI和Mb时AMI的敏感性为96.7%,特异性为88.0%;同时检测cTnI、Mb和CK-MB时AMI的敏感性为98.3%,特异性为88.0%,阳性预期值为95.2%,阴性预期值为88.0%。结论:cTnI、CK-MB和Mb联合检测对诊断AMI具有高度的敏感性和特异性,而且cTnI可作为评估发生因心血管死亡事件的独立风险因子。
OBJECTIVE: To quantitatively analyze and compare the cardiac troponin I, CK-MB and Mb in the early diagnosis and risk prediction of acute myocardial infarction (AMI) Reliable detection index. Methods: The quality of cTnI, CK-MB and Mb were measured in 85 patients with acute coronary syndrome (ACS) within 24 hours after admission to investigate their sensitivity and specificity to AMI. Results: The sensitivity of cTnI, CK-MB and Mb to AMI within 24 h after admission was 93.3%, 86.7% and 78.3%, respectively, with specificity of 100%, 100% and 88.0%, respectively. The sensitivity and specificity of AMI were 96.7% and 88.0%, respectively. The sensitivity and specificity of simultaneous detection of cTnI, Mb and CK-MB were 98.3%, 88.0%, 95.2%, and 88.0% respectively %. Conclusion: The combined detection of cTnI, CK-MB and Mb is highly sensitive and specific for the diagnosis of AMI, and cTnI can be used as an independent risk factor for cardiovascular death.