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目的：探讨细胞间粘附分子－１（ＩＣＡＭ－１）在肾小球炎症过程中的作用及氯沙坦对其影响。方法：采用体外肾小球系膜细胞与巨噬细胞共同培养的方法，观察抗ＩＣＡＭ－１ ＭｃＡｂ 对巨噬细胞促进系膜细胞增殖的影响及氯沙坦对其保护作用。结果：抗ＩＣＡＭ－１ ＭｃＡｂ 对巨噬细胞促进系膜细胞的增殖具有抑制作用，呈现剂量依赖趋势；氯沙坦（０．１，１．０，１０．０ μｍ ｏｌ／Ｌ）可明显抑制经血管紧张素Ⅱ（Ａｎｇ Ⅱ）诱导后系膜细胞与巨噬细胞的粘附。结论： ＩＣＡＭ－１ 参与、影响肾小球炎症过程，氯沙坦在肾脏疾病的防治中可能有一定的意义。
Objective: To investigate the role of intercellular adhesion molecule-1 (ICAM-1) in glomerular inflammation and the effect of losartan on it. Methods: Co-culture of glomerular mesangial cells and macrophages in vitro was used to observe the effect of anti-ICAM-1 McAb on the proliferation of mesangial cells induced by macrophages and the protective effect of losartan. RESULTS: Anti-ICAM-1 McAb inhibited the proliferation of mesangial cells induced by macrophages in a dose-dependent manner. Losartan (0.1, 1.0, 10.0 μmol / L) Adhesion of mesangial cells to macrophages induced by angiotensin Ⅱ (Ang Ⅱ). CONCLUSION: ICAM-1 is involved in the process of glomerular inflammation and losartan may play a role in the prevention and treatment of renal diseases.