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目的对比观察重组人表皮生长因子(rhEGF)、碱性成纤维细胞生长因子(bFGF)及氧氟沙星滴眼液对角膜上皮损伤修复的影响。方法行翼状胬肉切除术患者60例60眼,随机分为rhEGF(A)、bFGF(B)和氧氟沙星(C)三组(n=20),常规予三种滴眼液治疗7d,随访记录24、36、48、60、72h及4、5、6、7d时角膜上皮恢复情况。结果三组均于治疗36h起效,72h时A组、B组疗效优于C组,A组、B组4d和C组6d时均痊愈。结论 rhEGF和bFGF有促进角膜上皮损伤修复作用,可明显缩短角膜上皮损伤修复所需时间。
Objective To compare the effects of recombinant human epidermal growth factor (rhEGF), basic fibroblast growth factor (bFGF) and ofloxacin eye drops on corneal epithelial injury. Methods Sixty patients (60 eyes) with pterygium resection were randomly divided into rhEGF (A), bFGF (B) and ofloxacin (C) three groups (n = 20) The corneal epithelial recovery was observed at 24, 36, 48, 60, 72h and 4, 5, 6 and 7 days. Results All the three groups were effective at 36h after treatment. The efficacy of group A and B was better than that of group C at 72h, and recovered at 4 and 6 d respectively in group A and group B. Conclusion rhEGF and bFGF can promote the repair of corneal epithelial injury, which can shorten the time of corneal epithelial injury repair.