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目的 :观察子宫内膜癌的组织学类型与CEA、c erbB 2表达 ,探讨其组织学发生。方法 :光镜观察组织学形态并进行分型 ,应用免疫组化S P法 ,对 94例子宫内膜癌进行单克隆抗体CEA和c erbB 2检测。结果 :子宫内膜样癌 6 1例 (6 4.8% ) ,腺棘癌 6例 (6 .3% ) ,腺鳞癌 8例 (8.4% ) ,浆液性乳头状腺癌 7例 (7.4% ) ,粘液性癌 5例 (5 .3% ) ,小细胞癌 4例 (4.2 % ) ,透明细胞癌和鳞癌各 1例 (1.6 % )。内膜癌各亚型中以粘液性癌、腺棘癌和腺鳞癌CEA表达较高 ,而内膜样癌阳性表达少 ,仅见腔缘阳性 ;c erbB 2在各型内膜癌中均有表达 ,差异无显著性 (P >0 .0 5 )。结论 :各型内膜癌均有不同程度的CEA和c erbB 2的表达 ,与组织学类型无关 ;子宫内膜癌的多种组织学类型来源是苗勒氏管上皮多向分化的结果。
Objective: To observe the histological types of endometrial carcinoma and the expression of CEA and c erbB 2, and to explore their histological appearance. Methods: Histopathology was observed with light microscopy and typed. The immunohistochemical SP method was used to detect the expression of CEA and c erbB 2 in 94 cases of endometrial carcinoma. Results: There were 6 cases of endometrial carcinoma (6 4.8%), 6 cases of adenocarcinoma (6.3%), 8 cases of adenosquamous carcinoma (8.4%), 7 cases of serous papillary adenocarcinoma (7.4%), , 5 cases of mucinous carcinoma (5.3%), 4 cases of small cell carcinoma (4.2%), 1 case of clear cell carcinoma and squamous cell carcinoma (1.6%). Endometrial cancer in each subtype of mucinous carcinoma, adenocarcinoma and adenosquamous carcinoma CEA expression was higher, while the endometrial carcinoma positive expression less, only the edge of the cavity was positive; c erbB 2 in all types of endometrial cancer The difference was not significant (P> 0.05). CONCLUSION: The expressions of CEA and c erbB 2 are different in all types of endometrial carcinomas, which are not related to the histological type. The sources of multiple histological types of endometrial carcinoma are the result of multi-directional differentiation of Müllerian epithelium.