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自从Morawitz(1903)提出经典的血液凝固学说以来,已有五十多年。这个现在看来基本上还是正确但欠完善的学说,作为一个很有用的假说达三四十年之久。在这期间,由于血液在凝固现象出现以前整个凝固过程都是在看不见的情况下进行,无法进行观测,以致造成了在研究上的一定困难,而使血液凝固方面的知识长久处在一个停滞不前的状态。直到1935年Quick氏创立了一期法测定凝血酶元时间的方法后始为血液凝固化学的发展开辟了一个新纪
More than fifty years have passed since Morawitz (1903) proposed the classical theory of blood clotting. This theory, which now appears to be basically correct but imperfect, has served as a useful hypothesis for thirty or forty years. During this period, since the whole coagulation process was invisible before the coagulation phenomenon occurred, blood could not be observed, resulting in certain difficulties in research, leaving the knowledge of blood coagulation to stay at a standstill Unprecedented state. It was not until 1935 when Jean’s first method of determining the thrombin time was established to open up a new discipline for the development of blood clotting chemistry