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目的分析青年小细胞肺癌患者临床特征,为临床医学治疗及研究提供思路。方法从北京胸科医院2008年1月~2016年7月收治的1685例小细胞肺癌患者中,仅有28例患者年龄为35岁及以下。对他们的的临床资料进行分析,包括发病诱因、发病部位、临床分期及预后。结果本组病例中,有吸烟史者仅8例(28.6%),且除去2例患者吸烟指数大于400之外,其余吸烟指数均较低。2例局限期患者行新辅助化疗后手术并继续术后辅助放化疗者,目前仍定期复查无进展。结论吸烟在青年小细胞肺癌患者的发病诱因中并不占有主要地位。早期诊断、避免误诊及漏诊对于青年小细胞肺癌患者的预后极其重要。
Objective To analyze the clinical characteristics of young patients with small cell lung cancer and to provide ideas for clinical treatment and research. METHODS: Of the 1685 small cell lung cancer patients admitted to Beijing Chest Hospital from January 2008 to July 2016, only 28 patients were 35 years of age or younger. Analysis of their clinical data, including the incidence of incentives, the incidence of disease, clinical stage and prognosis. Results In this group of patients, there were only 8 patients (28.6%) who had a history of smoking, and the smoking index of 2 patients except the 2 patients was more than 400, the other smoking indexes were lower. Two patients with limited-term neoadjuvant chemotherapy and postoperative adjuvant radiochemotherapy were still regularly reviewed without progress. Conclusion Smoking does not occupy a major position in the pathogenesis of young patients with small cell lung cancer. Early diagnosis, to avoid misdiagnosis and missed diagnosis for the prognosis of young patients with small cell lung cancer is extremely important.