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目的观察氯吡格雷应用于急性冠脉综合征的疗效。方法将我院急性冠状动脉综合征(ACS)患者92例随机分为两组,两组均常规使用冠心病二级预防药物,治疗组于以上治疗基础上加用氯吡格雷首剂负荷量300mg,以后75mg,1次/d,随访时间1年,观察两组第1周心绞痛控制情况及1年内心血管事件发生率,进行比较。结果治疗组用药后第1周心绞痛控制情况及1年内心血管事件发生率均优于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷应用于急性冠脉综合征,效果可靠,无明显不良反应,值得临床推广应用。
Objective To observe the effect of clopidogrel in acute coronary syndrome. Methods 92 patients with acute coronary syndrome (ACS) in our hospital were randomly divided into two groups, two groups were routinely used secondary prevention of coronary heart disease, the treatment group on the basis of the above treatment plus clopidogrel first dose of 300mg , After 75mg, 1 time / d, follow-up time of 1 year, the first two weeks of angina control and cardiovascular events within 1 year were observed and compared. Results The angina control and the incidence of cardiovascular events in the first week after treatment in the treatment group were better than those in the control group, with statistical significance (P <0.05). Conclusion Clopidogrel is used in acute coronary syndromes with reliable results and no obvious side effects. It is worthy of clinical application.