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采用微孔聚四氟乙烯（PTFE）管引导大鼠坐骨神经再生模型，综合评价该技术的远期效果．方法：36只rrrrrrrrrnWistar大鼠随机分为2组，切断右侧坐骨神经：①对照组（n一18）：采用经典的外膜缝合法修复；②PTFE实验组（n一18）：以直径 2 mm PTFE管套接修复．术后 6及 9 mo进行电生理学检查、测量胖肠肌重量恢复率（GWR）、观察再生神经形态并行图像分析．结果：术后 6 mo，PTFE管内再生神经粗细均匀，无沙漏状改变；对照组神经传导速度（NCV）恢复率6O． 86％， PTFE组 54 36％（P＞ O． OS）；对照组 GWR为SO．89％，PTFE组 46． 11％（P＞O．OS）．术后 9 mo，对照组NCV恢复率65 99％，试验组58 79％（P＞O．OS）；对照组GWR为52．56％，试验组47 89％（P＞o．o5）．再生神经纤维形态正常，无受压征象．结论：综合以上结果和图像分析，认为PTFE修复神经后，再生纤维可以在免受压迫、有利神经营养、神经趋化因子发挥作用的微环境下逐渐成熟，其形态、功能等特性不逊于经典的外膜修复法．
Microporous polytetrafluoroethylene (PTFE) tube was used to guide the rat model of sciatic nerve regeneration, and the long-term effect of this technique was evaluated comprehensively. Methods: Thirty-six Wistar rats were randomly divided into two groups, the right sciatic nerve was cut off: ① control group (n = 18): the classic Membrane suture repair; ②PTFE experimental group (n-18): 2 mm diameter PTFE tube socket repair. Electrophysiological examination was performed 6 and 9 months after operation to measure the weight recovery rate (GWR) of the muscle and to observe the parallel neuronal morphology. Results: After 6 months, the thickness of regenerated nerve in PTFE tube was uniform and no change of hourglass shape was found. The recovery rate of nerve conduction velocity (NCV) in control group was 60%. 86% PTFE group 54 36% (P> O. OS); control group GWR is SO. 89% PTFE 46. 11% (P> O.OS). At 9 months after operation, the recovery rate of NCV in the control group was 65 99%, 58 79% (P> O.OS) in the control group, 52.56% in the control group and 47 89% in the experimental group (P 0. 05). Nerve fiber morphology is normal, no compression signs. Conclusion: Based on the above results and image analysis, it is concluded that after the nerve is repaired by PTFE, the regenerated fiber can mature gradually in the microenvironment that is free from oppression, favorable neurotrophic and neurotrophic factors, and its morphology and function are not inferior to the classic Outer membrane repair method.