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统计6年来收治的急性脑梗塞患者312例的发病时间,发现脑梗塞在清晨4AM～10AM为发病高峰,并对52例脑梗塞患者急性期及42例健康者进行24h尿去甲肾上腺素(NE)分泌率,血浆组织型纤溶酶原激活物(t-PA)及其抑制物(PAI)活性测定,结果发现:脑梗塞组急性期清晨NE分泌率、PAI活性较晚间明显高(P<0.05),t-PA活性较晚间明显低(P<0.05);清晨尿NE分泌率PAI活性脑梗塞组明显高于对照组(P<0.05),t-PA活性较对照组显著低(P<0.05)。联系脑梗塞清晨为发病高峰段与上述检验异常的同步关系,提示尿NE、t-PA及PAI活性异常变化可能是脑梗塞发病的重要原因之一。
The incidence of cerebral infarction in 312 patients with acute cerebral infarction over the past 6 years was statistically analyzed. The peak incidence of cerebral infarction was found at 4 AM to 10 AM in the early morning and the urinary norepinephrine (NE) was detected in 52 patients with acute cerebral infarction and 42 healthy subjects ) Secretion and the activity of t-PA and PAI were measured. The results showed that the secretion rate of NE and the activity of PAI in the acute phase of acute cerebral infarction were significantly higher than those in the evening (P < 0.05). The activity of t-PA in early morning urine was significantly higher in PAI-activated cerebral infarction group than that in control group (P <0.05), t-PA activity was significantly lower than that in control group (P < 0.05). It is suggested that the abnormal changes of urinary NE, t-PA and PAI may be one of the important causes of cerebral infarction.