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目的:研究术前血浆瘦素水平与胃癌BNI及术后病理分期相关性。方法:收集永州市中心医院2012年10月至2014年11月确诊为原发性胃癌患者84例(实验组)以及34名明确排除胃癌的健康成人(对照组)的临床资料,通过比较两组人员营养状况指标、BMI及血浆瘦素水平,采用Speraman秩相关分析血浆瘦素水平与胃癌BNI及术后病理分析相关性。结果:术前,两组人员身体各项指标的对比,实验组患者胃癌BNI水平与对照组无明显差别(P>0.05);实验组人员的白蛋白、转铁蛋白、前白蛋白、总胆固醇及血红蛋白水平明显比对照组低,P<0.05,具有统计学意义;实验组人员血浆瘦素水平高于对照组人员,P<0.05,具有统计学意义。Speraman秩相关分析提示,实验组胃癌患者术前血浆瘦素水平与BIM呈负相关(P<0.05),有统计学意义,与术后病理分期呈正相关性(P<0.05),有统计学意义。结论:术前血浆瘦素水平与胃癌BNI及术后病理分期具有相关性,检测血浆瘦素水平对预后评估具有一定的临床价值。
Objective: To study the correlation between preoperative plasma leptin level and gastric cancer BNI and postoperative pathological stage. Methods: The clinical data of 84 patients with primary gastric cancer (experimental group) and 34 healthy adults with definite exclusion of gastric cancer (control group) from Yongzhou Central Hospital from October 2012 to November 2014 were collected. By comparing the clinical data of two groups Personnel nutritional status indicators, BMI and plasma leptin levels, using Speraman rank correlation analysis of plasma leptin levels and gastric cancer BNI and postoperative pathological analysis. Results: Compared with the control group, there was no significant difference in BNI level between the two groups (P> 0.05). The levels of albumin, transferrin, prealbumin, total cholesterol And hemoglobin levels were significantly lower than the control group, P <0.05, with statistical significance; the experimental group of plasma leptin levels were higher than the control group, P <0.05, with statistical significance. Speraman rank correlation analysis showed that preoperative plasma leptin level in gastric cancer patients was negatively correlated with BIM (P <0.05), which was statistically significant and positively correlated with postoperative pathological stage (P <0.05), with statistical significance . Conclusions: Preoperative plasma leptin level is correlated with BNI of gastric cancer and postoperative pathological stage. Detecting plasma leptin level has certain clinical value for prognosis evaluation.