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心肌缺血后温热的含血停搏液再灌注有助于最大限度地减少再灌注性损伤。本研究检验下述假设:再灌注时给予过量合血停搏液可抵消其益处,而且能导致心室机能抑制,死亡率接近给予正常血再灌注之后。31条狗在减压排空的转流时37℃全心缺血45分钟。6条狗接受正常血再灌注。25条接受温热的富含门冬氨酸/谷氨酸酶的含血停搏液,其中8条接受大剂量(3600±600ml),有17条接受有限剂量(1180±120ml)停搏液再灌注,均在10～20分钟内给予。另有5条狗事先无心肌缺血而予大剂量(5100±200ml)含血停搏液再灌注。给予大剂量合血停搏液而无心
Reperfusion of warm blood-containing cardioplegia after myocardial ischaemia helps to minimize reperfusion injury. This study examined the hypothesis that overdosing of cardioplegic solution during reperfusion can counteract its benefits and can lead to inhibition of ventricular function with mortality approaching that given after normal blood reperfusion. 31 dogs were anesthetized for 45 minutes at 37 ° C under reduced pressure and emptying. Six dogs received normal blood reperfusion. Twenty-five warm plasma aspartate / glutamase-containing blood cardiopleges were received, of which 8 received high doses (3600 ± 600 ml) and 17 received limited doses (1180 ± 120 ml) of cardioplegic solution Reperfusion, are given within 10 to 20 minutes. Another five dogs without myocardial ischemia in advance to large doses (5100 ± 200ml) blood cardioplegia reperfusion. Give large doses of blood cardioplegia and careless