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目的：阐明胶原与血清低密度脂蛋白（ＬＤＬ）之间的关系。方法：在体外制备了Ⅰ型胶原凝胶，观察可能影响氧化ＬＤＬ（ｏｘ－ＬＤＬ）与胶原结合的几种因素。结果：随着ＬＤＬ氧化程度增加，其与胶原的结合量也增加。结论：这种增加可能主要源于脂蛋白的负电性增加，ＬＤＬ聚集度增大则可降低ＬＤＬ与胶原的结合能力。另外，载脂蛋白Ｂ中赖、精、组、酪氨酸残基的化学修饰，可能在ｏｘ－ＬＤＬ与胶原的结合中起重要作用
Objective: To clarify the relationship between collagen and serum low density lipoprotein (LDL). Methods: Type Ⅰ collagen gel was prepared in vitro and several factors that may affect the binding of oxidized LDL (ox-LDL) to collagen were observed. Results: As the degree of LDL oxidation increased, the amount of its binding to collagen also increased. CONCLUSIONS: This increase may be mainly due to an increase in the negative charge of lipoproteins and an increase in the degree of LDL aggregation to reduce the binding capacity of LDL to collagen. In addition, apolipoprotein B in Lai, Jing, group, tyrosine residues in the chemical modification may play an important role in the ox-LDL and collagen binding