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过去几年内,终末期的糖尿病人数有所增加,美国比欧洲更甚。晚近10年内对糖尿病肾脏改变的研究非常活跃,特别是早期改变。糖尿病肾损害的最初期,主要表现为肾脏肥大和机能亢进,运动时有轻微白蛋白尿,通过肾功能试验,形态学的检查和放射肾图法来证实。以上这种改变,即早期的肾脏肥大—机能亢进综合征的概念业已成立,如果严格控制血糖,肾脏最初期的改变是可以逆转的。糖尿病性肾损害超过2年,其主要改变为肾小球基底膜增厚,系膜区扩大。从肾活检此时可分第1期改变和第2期改变,第1期肾脏改变至少部分可以逆
Over the past few years, the number of end-stage diabetes has increased, the United States even more than in Europe. In the recent 10 years, studies on the changes of diabetic kidney have been very active, especially in the early stage. The initial stage of diabetic nephropathy, mainly manifested as hypertrophy and hyperthyroidism, exercise, mild albuminuria, by renal function tests, morphological examination and radio kidney chart to confirm. The above change, the concept of early hypertrophy of kidney-hyperthyroid syndrome, has been established. If the blood sugar is strictly controlled, the initial changes in the kidney can be reversed. Diabetic nephropathy over 2 years, the main changes to the glomerular basement membrane thickening, mesangial area expanded. From the time of renal biopsy can be divided into the first phase of change and the second change, the first phase of renal changes can be at least partially reversible