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本文报告5例动脉或静脉血栓形成的病人,用肝素间歇静脉注射后8～13天发生严重血小板减少。当停用肝素后5天内其血小板数均恢复正常水平。为此,作者对这5例病人作了6周的观察,并检测血小板凝集性及血小板第3因子有效试验,以测定药物有关的抗血小板抗体。当肝素(0.5单位/毫升)加入病人的枸橼酸富血小板血浆中或加入含病人血清的正常
This article reports five patients with arterial or venous thrombosis who developed severe thrombocytopenia 8 to 13 days after intermittent intravenous heparin injection. Platelet count returned to normal levels within 5 days of discontinuation of heparin. To this end, the authors of these 5 patients were observed for 6 weeks and tested for platelet aggregation and platelet factor 3 effective test to determine drug-related anti-platelet antibodies. When heparin (0.5 units / ml) is added to the patient’s citrate-rich platelet plasma or added to the patient’s serum containing normal