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印度楝树是一种印度次大陆的本土树,其种子、叶和树皮及其制剂多年来已在医学上应用。最近发现从楝树种子中提取的楝树油对人和恒河猴有强力杀精子作用。阴道使用有抗着床和引产作用。该油可能成为一种有效的房事前、后的阴道避孕药。为了将该草药开发成为一种合适的阴道避孕药,作者应用水蒸气蒸馏操作从树油中分离出一种代号为NIM-76的无色挥发性成份,然后应用气相色谱(GC)和气相色谱-质谱分光(GC-MS)法分析其内含成份。本文主要报道体外评价NIM-76对人类和大鼠精子的杀精作用。250mg NIM-76溶在0.1ml 环己酮和0.5ml 吐
Neem is a native tree of the Indian subcontinent whose seeds, leaves and bark and their preparations have been used medically for many years. It has recently been found that neem oil extracted from neem seeds has potent spermicidal effects on humans and rhesus monkeys. Vaginal use of anti-implantation and induction of labor. The oil may become an effective pre and post vaginal pill. In order to develop the herb into a suitable vaginal pill, the authors used a steam distillation operation to separate a colorless, volatile component, codenamed NIM-76, from tree oil and applied gas chromatography (GC) and gas chromatography - Analysis by mass spectrometry (GC-MS) of its contents. This paper reports the in vitro evaluation of the spermicidal effect of NIM-76 on human and rat spermatozoa. 250 mg NIM-76 is dissolved in 0.1 ml cyclohexanone and 0.5 ml spit