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五十年代以来,人们已注意到冠心病患者的血清极低密度脂蛋白(VLDL)和低密度脂蛋白(LDL)平均浓度比健康人高。以后认识到 LDL 为动脉硬化的危险因子。国外用荧光免疫法测定血清VLDL 或 LDL 时发现,当二者水平增高时,动脉内膜下载脂蛋白(apo)中 apoB 数量大于其他 apo。因此,认为 apoB 是 VLDL 和 LDL 导致动脉粥样
Since the 1950s, it has been noticed that the average concentrations of serum VLDL and LDL in CHD patients are higher than those in healthy people. Later recognized LDL as a risk factor for atherosclerosis. Abroad with fluorescence immunoassay for the determination of serum VLDL or LDL found that when both levels increased, the number of apoB in the atherosclerotic apo was higher than in other apo. Therefore, apoB is thought to be caused by VLDL and LDL atherosclerosis