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目的探讨葡萄糖耐量试验在空腹血糖正常高脂血症患者早期诊断糖尿病中的应用价值。方法选择秦皇岛市第四医院体检确诊的100例空腹血糖正常的单纯高脂血症患者,行葡萄糖耐量试验(OGTT),2 h后测定受检者2 h血糖(2hPG),分析葡萄糖耐量降低(IGT)及糖尿病检出情况,并比较正常组、IGT组及糖尿病组患者FPG、2hPG、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、谷草转氨酶(AST)、谷丙转氨酶(ALT)水平。结果 OGTT检出IGT 37例(37%),糖尿病27例(27%);IGT组及糖尿病组2hPG较正常组显著升高(P<0.05、P<0.01);三组TG、TC、LDL-C均高于正常值,糖尿病组TG、TC、LDL-C较正常组显著升高(P<0.05),而IGT组TG、TC、LDL-C与正常组差异无统计学意义(P>0.05);三组ALT及AST均在正常范围内,组间差异无统计学意义(P>0.05)。结论 OGTT试验可早期诊断空腹血糖正常的高脂血症患者的糖代谢异常,值得临床推广应用。
Objective To investigate the value of glucose tolerance test in the early diagnosis of diabetes in patients with fasting plasma glucose-normal hyperlipidemia. Methods 100 cases of hyperlipidemia patients with normal fasting plasma glucose were diagnosed in the Fourth Hospital of Qinhuangdao City. The glucose tolerance test (OGTT) was performed. The 2 h blood glucose (2 hPG) IGT) and diabetes mellitus, and compared FPG, 2hPG, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), aspartate aminotransferase AST), alanine aminotransferase (ALT) levels. Results OGTT detected IGT 37 cases (37%), diabetes mellitus 27 cases (27%); IGT group and diabetic group 2hPG than the normal group was significantly higher (P <0.05, P <0.01) (P <0.05). However, TG, TC and LDL-C in IGT group were not significantly different from those in normal group (P> 0.05) ). The ALT and AST levels were within the normal range in the three groups, with no significant difference between the two groups (P> 0.05). Conclusion The OGTT test can diagnose the abnormal glucose metabolism in patients with hyperlipidemia with fasting plasma glucose, which is worthy of clinical application.