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目的:探讨川西地区学龄儿童抗DNA酶B抗体流行病学特点。方法:从1993年09月～1994年08月对四川省成都市青白江区城市和农村学龄儿童(年龄9～11岁),共197名(男113名,女84名)。每3个月抽血1次,用微量法统一测定血清抗DNA酶B抗体水平。结果:1.抗DNA酶B抗体滴度水平差异与季节、性别、地区关系:DNA酶B冬季稍高,其他三季相差小(P>0.05)。男性DNA酶B值高于女性DNA酶B值,其差异有统计学意义(P<0.05)。农村学生DNA酶B值冬季明显高于城市学生(P<0.05)2.DNA酶B与风湿热(RF)关系:DNA酶B随季节有一定变化,但尚未见统计学差异,以冬季稍高,而风湿热则明显秋冬季较高,两者流行趋势相似。结论:农村儿童青少年DNA酶B较城区几何滴度高,冬季较其他季节高均证实这一点。测定某一地区学龄儿童血清抗DNA酶B水平,可作为该地区RF流行水平的初步估测和进一步研究的参考。
Objective: To explore the epidemiological characteristics of anti-DNase B antibody in school-age children in western Sichuan. Methods: From September 1993 to August 1994, 197 schoolchildren (113 males and 84 females) were enrolled in this study. Schoolchildren aged 9-11 in Qingbaijiang District of Chengdu City, Sichuan Province, China. Blood was drawn every 3 months and serum anti-DNase B antibody level was determined by the trace method. The results showed that: 1. The relationship between anti-DNase B antibody titers and seasonal, gender and regional relationship: DNAzyme B slightly higher in winter and little difference in other three seasons (P> 0.05). Male DNA enzyme B value higher than female DNA enzyme B value, the difference was statistically significant (P <0.05). The DNase B value of rural students was significantly higher than that of city students in winter (P <0.05) .2 The relationship between DNase B and rheumatic fever (RF): DNase B had some changes with the seasons, but there was no statistical difference, , While rheumatic fever was significantly higher in autumn and winter, both similar to the popular trend. Conclusion: The DNA titers of DNase B in children and adolescents in rural areas are higher than those in urban areas, which is higher than those in other seasons in winter. Determination of serum anti-DNase B levels in school-age children in a certain area can be used as a preliminary estimation and further reference for the prevalence of RF in the area.