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DNA异常甲基化是人类肿瘤中常见的改变。发生在启动子区的CpG岛的异常甲基化是基因失活的最常见机制。某些基因甲基化与肺癌发生密切相关,且是肺癌发生中的早期事件。
Aberrant DNA methylation is a common alteration in human tumors. Aberrant methylation of CpG islands in the promoter region is the most common mechanism of gene inactivation. Methylation of some genes is closely related to the occurrence of lung cancer and is an early event in the development of lung cancer.