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目的 探讨谷胱甘肽s 转移酶 μ基因 (Glutathiones transferaseμ ,gstμ)缺失与三硝基甲苯 (trinitrotoluene ,TNT)白内障发病的关系。方法 采用多聚酶链反应 (polymerasechainreaction ,PCR)方法 ,对TNT白内障患者、其他类型白内障患者、健康人群等 3组样本共 2 3 5人的DNA进行了gstμ基因检测。 结果 TNT白内障患者组gstμ基因缺失率高达 65 6% ,与各对照组比较差异均有显著性 (P <0 0 5 ) ,以健康人群为对照计算的gstμ基因缺失者发生TNT白内障的OR值为 2 3 3 ;gstμ基因缺失与TNT白内障的发生呈显著相关 (P <0 0 5 )。 结论 gstμ基因缺失与TNT白内障的发病有密切关系
Objective To investigate the relationship between the deletion of glutathione S transferase μ (gstμ) and the incidence of cataract in trinitrotoluene (TNT). Methods The polymerase chain reaction (PCR) method was used to detect the gstμ gene in a total of 2 35 DNA samples of TNT cataract patients, other types of cataract patients and healthy subjects. Results The deletion rate of gstμ gene in TNT cataract patients was 65.6%, which was significantly different from that in control subjects (P <0.05). The OR of TNT cataract patients with gstμ deletion was There was a significant correlation between gstμ gene deletion and TNT cataract (P <0.05). Conclusion The deletion of gstμ gene is closely related to the incidence of cataract in TNT