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目的观察未经任何药物治疗急性中风患者血清甲状腺轴激素及泌乳素(PRL)水平的变化.方法检测22例脑出血患者和15例脑梗塞患者血清甲状腺素(T4)、三碘甲腺原氨酸(T3)、反T3(rT3)、促甲状腺素(TSH)及PRL的水平,并与27例正常人进行比较.结果急性中风患者血清T4、T3均值明显低于对照组,血清rT3、TSH均值明显高于对照组.血清PRL均值略高于对照组,但无统计学意义.血清T4、T3均低于对照组两个标准差者8例,其中死亡4例.结论:血清甲状腺轴激素检测有助于预测急性中风预后,低T3低T4综合征往往有恶劣的预后,应引以重视.
Objective To observe the changes of serum thyroid hormone and prolactin (PRL) levels in patients with acute stroke without any drug treatment. Methods Serum thyroxine (T4), triiodothyronine (T3), anti-T3 (rT3), thyrotropin (TSH) and PRL were measured in 22 patients with cerebral hemorrhage and 15 patients with cerebral infarction. 27 normal subjects were compared. Results The mean serum T4 and T3 levels in patients with acute stroke were significantly lower than those in the control group, and mean serum rT3 and TSH levels were significantly higher than those in the control group. Serum PRL mean slightly higher than the control group, but not statistically significant. Serum T4, T3 were lower than the control group of two standard deviations in 8 cases, of which 4 died. Conclusion: Serum thyroid hormone test can help predict the prognosis of acute stroke. Low T3 low T4 syndrome often has poor prognosis, which should be taken seriously.