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目前对儿童期乙型肝炎病毒携带者(简称携带者)的预后研究较少,特别是对婴幼儿携带者的肝脏变化不明之处甚多,为此,作者调查了年龄为0～15岁(平均为8.2±4.0岁)者62例,其中56例家庭成员有携带者,52例携带者为母亲。本文对HBe抗原抗体系统、临床经过、肝组织学动态变化等方面作了研究。观察时间平均29.2±28.7个月,其中1年以上的46例,最长达96个月。结果(1)HBe抗原抗体检出情况和临床变化:初诊时51例HBeAg阳性,9例抗-HBe阳性,2例两者均阴性。HBe抗原、抗体检出与性别无关。
At present, children with hepatitis B virus carriers (referred to as carrier) prognosis of less, especially for infants and young children carrying a lot of changes in the liver is unknown, therefore, the authors investigated the age of 0 to 15 years ( Average 8.2 ± 4.0 years) 62 cases, of which 56 family members have carriers, 52 carriers were mothers. In this paper, HBe antigen antibody system, clinical course, the dynamic changes of liver histology were studied. The average observation time was 29.2 ± 28.7 months, of which 46 cases were more than one year, up to 96 months. Results (1) Detection of HBe antigen and clinical changes: 51 cases of HBeAg positive, 9 cases of anti-HBe positive, two cases of both negative. HBe antigen, antibody detection has nothing to do with gender.