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钙拮抗剂能抑制鼠胰岛细胞分泌胰岛素,主要用于治疗缺血性心脏病和高血压的药物可能降低糖耐量,对糖尿病人有持殊的重要性.作者研究了硝苯吡啶和尼可地平对非胰岛素依赖性糖尿病人糖耐量和胰岛素浓度的影响.用双盲随机交叉法调查了20名非胰岛素依赖性糖尿病人.病人禁食后做糖耐量试验,治疗前后共做4次.在治疗12周内观察病人,病人分别接受硝苯吡啶(10mg/8h)和等效量的尼可地平(30mg/8h)4周,间隔使用安慰剂4周.禁食后静脉采血测定血中糖胰岛素和HbA_1,然后病人服75g葡萄糖,每30min采一次血,持续150min,测定血糖和胰岛素.
Calcium antagonists can inhibit the insulin secretion of rat pancreatic islet cells, mainly for the treatment of ischemic heart disease and high blood pressure drugs may reduce impaired glucose tolerance in patients with a special importance of the study of nifedipine and nikolapin On impaired glucose tolerance and insulin concentration in non-insulin dependent diabetes mellitus Twenty non-insulin dependent diabetic patients were investigated by a double-blind randomized crossover study.The patients were fasted for glucose tolerance test 4 times before and after treatment Patients were observed within 12 weeks, nifedipine (10mg / 8h) and the equivalent amount of nifedipine (30mg / 8h) for 4 weeks, placebo for 4 weeks interval after fasting venous blood was measured glucose in blood insulin And HbA_1, then the patient served 75g of glucose, blood was collected every 30min, sustained 150min, determination of blood glucose and insulin.