氯乙烯和酒精对脂质过氧化及对微粒体酶的联合作用

• 作 者: 吴旭增 刘世杰 江泉观 崔京伟
• 机 构: 北京医学院临床药理研究所,北京医学院劳动卫生教研室,北京医学院劳动卫生教研室,北京医学院劳动卫生教研室
• 出 处: 生理科学
• 发表日期: 1984年01期
• 关键词: 脂质过氧化 氯乙烯 微粒体酶 酒精 诱导剂 酒精组 大鼠肝微粒体 短期 微粒 器官水平

作者等已相继报告,氯乙烯可诱导微粒脂质过氧化并影响微粒体酶的活性,酒精可诱导线粒体脂质过氧化,但对微粒体酶无影响。氯乙烯和酒精对脂质过氧化及对微粒体的联合作用,迄今国内外均未见报道。已知P_450的诱导剂巴此妥能加强氯乙烯的过氧化作用,而酒精急性或短期处理不能诱导P_450,因而设想它对氯乙烯诱导的脂质过氧化无加强作用。本文通过体外和整体实验,研究两者的联合作用,为研究氯乙烯的过氧

The authors have reported, vinyl chloride can induce lipid peroxidation and affect microsomal enzyme activity, alcohol can induce mitochondrial lipid peroxidation, but no effect on microsomal enzymes. Vinyl chloride and alcohol on lipid peroxidation and the combined effect of microsomal, so far have not been reported at home and abroad. It is known that the P_450 inducing agent, Barndhal, can enhance the peroxidation of vinyl chloride. However, acute or short-term alcohol treatment fails to induce P_450. Therefore, it is envisaged that it will not exert an effect on vinyl chloride-induced lipid peroxidation. In this paper, in vitro and in vivo experiments to study the combined effect of the two, for the study of vinyl peroxide