In silico identification of potential inhibitors targeting Streptococcus mutans sortase A

• 作 者: Hao Luo Dan-Feng Liang Min-Yue
• 机 构: SchoolofLifeSciencesandKeyLaboratoryofMinistryofEducationforBio-ResourcesandBio-Environment,StateKey
• 出 处: 国际口腔科学杂志：英文版
• 发表日期: 2017年1期
• 基金项目: supported in part by the National Natural Science Foundation of China (Nos 31300674,81173093,30970643,81373311 and J1103518),,the Special Programme for Youth Science and the Technology Innovative Rese

Dental caries is one of the most common chronic diseases and is caused by acid fermentation of bacteria adhered to the teeth.Streptococcus mutans(S. mutans) utilizes sortase A(Srt A) to anchor surface proteins to the cell wall and forms a biofilm to facil