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本文应用Nashed等人建立的大鼠腹膜细胞短期致癌试验法检测了现市场上应用的外用杀精子避孕药烷苯醇醚的潜在致癌性。实验结果:生理盐水、壬苯醇醚、以及烷苯醇醚的两个剂量(4 mg/kg和40 mg/kg)处理的大鼠,其腹膜细胞经体内外短期培养均未见有大于9个细胞的集落产生。而甲基亚硝基胍处理的大鼠,则可见9～30个细胞的集落(13.5±8.6个/20个高倍视野),且还可见100个细胞以上的巨大集落。依据判定指标表明烷苯醇醚无明显潜在的致癌作用。结合致畸和致突变实验结果证明该药是比较安全的。
In this paper, Nasda et al. Established a rat peritoneal short-term carcinogenicity assay to test the potential carcinogenicity of the topical spermicide contraceptive alkylbenzene ether used on the market. Experimental results: Rats treated with two doses (4 mg / kg and 40 mg / kg) of normal saline, nonoxynol, and alkylbenzene ether had no more than 9 peritoneal cells cultured in vitro or in vivo Colonies of one cell are produced. In the group treated with methylnitrosoguanidine, colonies of 9 to 30 cells (13.5 ± 8.6 cells / 20 high power fields) were observed, and large colonies of more than 100 cells were also observed. Based on the determination of indicators show that no obvious potential carcinogenic alkyl benzene alcohol. Combined with teratogenic and mutagenic experimental results show that the drug is relatively safe.